Re: clonazepam/Klonopin and HPA axis issues

Posted by SLS on December 22, 2012, at 13:57:13

In reply to Re: clonazepam/Klonopin and HPA axis issues » Beeb, posted by gadchik on December 22, 2012, at 13:02:04

> Ive also read that klonopin increases/decreases or just affects serotonin in some way.
Yup. Confusing, isn't it? I have seen the older studies, and they do report contradictory results.
When I discontinued chronic Klonopin (clonazepam) and went through withdrawal, I experienced severe "brain-zaps" that I don't recall experiencing with Ativan (lorazepam) discontinuation. It was reminiscent of SSRI / SNRI withdrawals. I wonder if this is an artifact of changes in 5-HT function produced by clonazepam. One would think that the brain-zaps would be consistent with a sudden decrease in 5-HT activity. Does this mean that clonazepam somehow enhances 5-HT neurotransmission?
This study is old, but looks pretty good:
http://www.ncbi.nlm.nih.gov/pubmed/520416

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

Thread

clonazepam/Klonopin and HPA axis issues Beeb 12/22/12
Re: clonazepam/Klonopin and HPA axis issues » Beeb gadchik 12/22/12
Re: clonazepam/Klonopin and HPA axis issues » Beeb SLS 12/22/12
Re: clonazepam/Klonopin and HPA axis issues SLS 12/22/12
Re: clonazepam/Klonopin and HPA axis issues Phillipa 12/22/12
Re: clonazepam/Klonopin and HPA axis issues Beeb 12/22/12
Re: clonazepam/Klonopin and HPA axis issues Beeb 12/22/12
Re: clonazepam/Klonopin and HPA axis issues Beeb 12/22/12
Re: clonazepam/Klonopin and HPA axis issues Beeb 12/22/12
why some brains can withdraw and others not??? gadchik 12/22/12
Re: why some brains can withdraw and others not??? » gadchik Phillipa 12/22/12
Re: why some brains can withdraw and others not??? » gadchik SLS 12/22/12
Re: why some brains can withdraw and others not??? » SLS Phillipa 12/22/12
Re: clonazepam/Klonopin and HPA axis issues jono_in_adelaide 12/22/12
Re: clonazepam/Klonopin and HPA axis issues » jono_in_adelaide SLS 12/22/12
Re: why some brains can withdraw and others not??? » SLS gadchik 12/23/12
...
Re: clonazepam/Klonopin and HPA axis issues Beeb 12/28/12

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