Posted by Brainbeard on July 27, 2012, at 13:31:32
In reply to Re: Brainbeard in psychopharmacotherapeutical heaven » Brainbeard, posted by phidippus on July 26, 2012, at 21:09:25
> 250 mg of Zoloft! Jeezus, you're heading for seratonin syndrome. Why even bother with the Clomipramine?
>Hi Eric, always good to hear from you;
Serotonin syndrome is a myth, mostly. I'm not saying that it doesn't exist; but it's very rare to begin with, and apart from that it can be caused by ANY SRI on its lonely self, even a weak one like Effexor (venlafaxine), and even on a moderate dose. I don't believe that with the heights of SRI I had already reached with clomipramine + fluvoxamine, and longer ago on Paxil (paroxetine), I will be surprised by serotonin syndrome anymore.
Serotonin syndrome is feared much too much in light of its rarity; also, it doesn't make sense that it is particularly feared when combinations of SRI's are used, since combining SRI's doesn't seem to be what causes it in the first place.
Why even bother with the clomipramine? Well, I'm trying to taper off of it (I'm on only 37.5mg now), but that's because of the dry mouth it gives me plus the anticholinergic dumbing; clomipramine is a superb drug otherwise, and it has a strong advantage over SSRI's, since it doesn't make one listless, but rather keeps adrenaline pumping because of its strong NRI properies. I have yet to see wether Zoloft on its own leaves me listless or not.
How are you, by the way?
Current meds: Zoloft (sertraline) 250mg, Neurontin (gabapentin) 1800mg, clomipramine 75mg, Concerta 18mg + methylphenidate (Ritalin) 5mg a time, flupentixol 0,5mg. PRN: alprazolam, clonazepam.
poster:Brainbeard
thread:1021657
URL: http://www.dr-bob.org/babble/20120718/msgs/1022228.html