Posted by SLS on July 22, 2012, at 0:27:08
In reply to my plan i thought up, posted by poser938 on July 20, 2012, at 19:38:52
I don't necessarily agree with your conclusions, but I don't discount them. At low dosages sulpiride and amisulpride block D2 presynaptic autoreceptors preferentially, presumably resulting in an increase in synthesis and release of dopamine.
Abilify would be an interesting drug to try if you are looking to "stabilize" your limbic dopamine system as per Stephen Stahl.
Abilify is a potent postsynaptic D2/D3 receptor partial agonist. However, it is also a presynaptic full agonist. The net effect, though, is dependent upon the state of the system.
"In animal models, under hyperdopaminergic conditions, binding of aripiprazole resulted in decreased activation of D2 receptors, whereas in hypodopaminergic states, administration resulted in activation of D2 receptors."
- Kikuchi T, Tottori K, Uwahodo Y, et al. 7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl] butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity. J Pharmacol Exp Ther 1995;274(1):329-36.
Perhaps you would respond to ketamine.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1021868
URL: http://www.dr-bob.org/babble/20120718/msgs/1021917.html