Posted by europerep on November 11, 2011, at 14:08:54
In reply to Re: Triple reuptake inhibitor GSK372475 fails. » SLS, posted by ed_uk2010 on November 11, 2011, at 5:44:38
Is there any reason to believe that a TRI is actually more effective than a combination of, say, venlafaxine and bupropion?
Ok, I get it, combining agents may produce synergistic side effects and having to take several different meds decreases patient compliance, so I probably shouldn't bash those agents, but still... I don't think TRIs have a significantly greater antidepressant potential than the combination of agents that add up to triple reuptake inhibition.
I don't think the solution for treatment-resistant depression lies in drugs like vilazodone or TRIs. They may be more tolerable for those remit on "old" monoaminergic drugs, which is great, but they won't make the number of TRD patients go down a lot.
poster:europerep
thread:1002099
URL: http://www.dr-bob.org/babble/20111110/msgs/1002283.html