Posted by Pickles on August 2, 2011, at 12:01:45
In reply to Re: MAOI Trial, posted by desolationrower on July 30, 2011, at 21:42:15
> > Hi Oliver,
> >
> > I've been involved with a study for a new MAOI (one that isn't binding so there are fewer food restrictions). I have to be honest, I'm not seeing much of a difference...wondering if I got the placebo (just my luck!)
> >
> > I've read a lot about MAOI's but the food restrictions scare me...not so much the fact that I can't eat a lot of things that I like but more so, if I'm out to dinner and there's something in the food that I'm not aware of...scary. Who wants to be known as the person who died from the dreaded "cheese death"? ...no me! :)
> >
> > Before I could start the study I had to ween myself off of Prozac...the though of being without an antidepressant for 4 weeks scared me but actually, I came to realize that Prozac really wasn't working for me. I felt better (less of a foggy feeling, same amount of depression) after I stopped.
> >
> > I talked to the director (doctor) running the research about what I should take after the study is over...she recommended I look into something called Emsam. Going to do a bit of research on it now...
> >
> > Good luck to you!
> >
> > P.
>
> meaning it is reversable? i have been hoping the tissues specific MAOIs finally make it to market sometime.
>
> -d/rI obviously don't know the name of the drug I'm taking since it's still being tested but here is something I found on Wikipedia about Harmaline, another MAOI..."The reversibility means that, instead of binding permanently to MAO-A for weeks until the body replaces the MAO-A enzyme molecules, harmaline binds only transiently, so tyramine can be metabolized as well by competing with harmaline for the binding site on the enzyme. This means that the risk of a hypertensive crisis, a dangerous high blood pressure crisis from eating tyramine-rich foods such as cheese, is potentially lower with harmaline than with non-reversible MAOI's such as Nardil, especially after 24 hours following ingestion." So, with the test meds, we still have to be careful about what we eat but the list of foods to avoid is significantly shorter than the list for a binding MAOI.
I do have to say that I really hope I'm on the placebo...I've never taken an MAOI but I've heard/read that they do wonders for depression and social anxiety. I'm on my fifth week of a six week study and, although I do feel a bit better at times, I was expecting a lot more...
poster:Pickles
thread:988840
URL: http://www.dr-bob.org/babble/20110728/msgs/992582.html