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Fluanxol, tardive dyskinesia

Posted by NKP on April 20, 2011, at 13:41:08

According to Wikipedia:

"Flupentixol acts as an antagonist at various dopamine (D1-D5), serotonin (5-HT2), adrenaline (α1), and histamine (H1) receptors, without affecting the muscarinic acetylcholine receptors.

Its antipsychotic effects are likely caused by D2 and/or 5-HT2A antagonism, whereas its antidepressant effects at lower doses may be mediated by preferential D2/D3 autoreceptor blockade, resulting in increased postsynaptic activation."

(http://en.wikipedia.org/wiki/Fluanxol)

Since Fluanxol blocks the dopamine autoreceptor at lower doses, would this lessen the risk of tardive dysknesia?


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