Posted by linkadge on September 10, 2010, at 16:58:08
In reply to Re: nortripytline + MAOi? anti histamine interraction, posted by Conundrum on September 10, 2010, at 15:18:51
>Nortriptyline doesn't block all transporters and >MAO inhibitors can actually be used to lower >blood pressure. They actually end up decreasing >blood pressure I believe this works through >something called octapine or something.
You mean octopamine. Sometimes MAOIs lower blood pressure, sometimes not. Both my blood presure and heart rate increased on parnate. The increase in heart rate was distrubing. Same thing with nortriptyline. I don't feel comfortable with my heart beating >100 bpm.
>So there
>is a difference between MAO B depleted h rats on >paper and MAO inhibitors in vivo.Every drug or combination has side effects. I wouldn't refer to any combination as being 'sic' without first taking it. The point I'm trying to make is a lot of combos might seem great in theory, but clinically they might not pan out.
Go ahead and take selegiline + nortriptyline, I really don't care. See what it does for you. Mood is a lot more complicated than just boosting serotonin norepinephrine and dopamine. I mean, reserpine used to be used for anxious depression.
Linkadge
poster:linkadge
thread:961847
URL: http://www.dr-bob.org/babble/20100908/msgs/961983.html