Posted by Brainbeard on August 6, 2010, at 15:33:59
In reply to Re: Clomipramine plasma levels and clinical outcome » Brainbeard, posted by ed_uk2010 on August 6, 2010, at 14:59:29
It does involve guesswork. Subjective measurements are suspect by nature, especially when dealing with hypochondrics and people focused on negative experiences.
Blood work (and, true, EKG's and the like) can help with enduring unpleasant side-effects, since it gives the patient an objective counter-value against which to evaluate such side-effects.
Clomipramine has non-linear pharmacokinetics: on higher doses, blood levels increase exponentially in relation to dose, supposedly because of its self-inhibiting metabolism. People have died from toxic doses without experiencing severe side-effects in advance.
Current meds: clomipramine 75mg, fluvoxamine 25mg.
poster:Brainbeard
thread:956845
URL: http://www.dr-bob.org/babble/20100731/msgs/957536.html