Posted by SLS on July 23, 2010, at 16:15:35
In reply to Re: toxic crap, posted by TenMan on July 23, 2010, at 14:52:50
> Personally, I would be more concerned about the toxicity lifelong chronic depression can have on quality of life.
...and the entire central nervous and endocrine systems.
Personally, I would take the risk with nortriptyline and this BBB stuff, should one even exist. I would want to see some corroborative evidence of such risks produced since the 1972 report was published for me to contemplate discontinuing nortriptyline. That is just me, though. Even if one were to take the authors at their word, they state quite firmly that anomalies in BBB were not seen with therapeutic concentrations of nortriptyline. Similarly, there are cardiotoxic effects that do not emerge until dosages above the therapeutic range are reached.
The problem I have with nortriptyline is that it doesn't work for me monotherapeutically. I find that it is somewhat helpful when combined with other drugs. My only robust drug responses have been in association with combinations of MAOI and TCA. Perhaps it is a matter of the magnitude of pain and debilitation that motivates some people to choose to take risks, known and unknown.
- Scott
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:955512
URL: http://www.dr-bob.org/babble/20100720/msgs/955652.html