Posted by SLS on May 4, 2010, at 15:28:32
In reply to Re: Frustration » SLS, posted by conundrum on May 4, 2010, at 11:46:44
> Yeh I was thinking the brand might be better but then I remember tinnitus was listed as a side effect in the original brand trials, so I'm not sure about that. I didn't even know lamictal increased DA release, thats odd since too much DA causes psychosis doesn't it and its often used as a mood stabilizer for BP. Most drugs for BP like antipsychotics block DA. Thats interesting.
As best as I can recall, glutamatergic circuits efferent from the PFC project into the nucleus accumbens and inhibit dopamine release there. Lamotrigine inhibits glutamate release in the PFC and thus disinhibits (allows) the release of dopamine. Glutamate antagonists can be psychotogenic. I have heard of people having manic reactions to lamotrigine.
- Scott------------------------------------------
Psychopharmacology (Berl). 2008 Dec;201(3):325-38. Epub 2008 Aug 28.
Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity.http://www.ncbi.nlm.nih.gov/pubmed/18751970
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:945983
URL: http://www.dr-bob.org/babble/20100504/msgs/946315.html