Posted by bearfan on March 5, 2010, at 1:33:17
In reply to Re: SSRI vs SNRI - Efficacy Comparison Article (lo, posted by West on August 10, 2008, at 7:52:28
Good write up. Although it was theorized that SNRIs have better efficacy, it gets cloudy because some patients may not need additional Norepinephrine or Additional Serotonin. Some patients have more of a psychological aspect of depression and would do better on an antidepressant that is the most tolerable to them. There was a scientific study posted last year on top antidepressants on grounds of efficacy and tolerability and Remeremon (a novel SNRI like drug) and a specific serotonin reuptake inhibitor (escitolapram) were near the top of the lists. Also most SSRIs have some effect on NE and even DE so they are not strictly SSRI, even most SNRIs have a predominance of sertonin reuptake. Eli Lilly originally developed an NRI, Atomoxetine, as an antidepressant, but it failed so they marketed for ADD like symptoms. It appears that depression, and more likely anxiety/stress tends to sometimes be more serotonin linked. While not excluding links to dopamine and norepinephrine.
poster:bearfan
thread:844518
URL: http://www.dr-bob.org/babble/20100216/msgs/938595.html