Posted by SLS on January 7, 2010, at 19:02:46
In reply to Re: Amisulpride (Solian) + Pramipexole (Mirapex) ? » linkadge, posted by SLS on January 7, 2010, at 18:58:37
> > Might be have some counterproduction as mirapex has some agonist affinity for presynaptic dopamine autoreceptors and solan has some antagonist affinity?
>
> I hadn't considered that. It would depend upon which drug has the greatest affinity for the presynaptic receptor. Amisulpride is pretty sticky. Maybe I'll go check out PDSP.You want the amisulpride to antagonize the presynaptic receptor without binding to the postsynaptic receptor. This is what occurs at low dosages. Pramipexole would then be blocked from interacting with the presynaptic receptor and yet be allowed to stimulate the postsynaptic receptor. The net effect might be an increase in dopaminergic tone.
Who knows? It sounded good at the time. You had to be there.
:-)
- Scott
poster:SLS
thread:932861
URL: http://www.dr-bob.org/babble/20100103/msgs/932870.html