Posted by SLS on January 4, 2010, at 23:43:10
In reply to Re: up to 120mg Parnate- hypotension getting dange » floatingbridge, posted by inanimate peanut on January 4, 2010, at 20:38:37
> As for what I'm going to do, I suppose I will have to go back to 60mg. I'm afraid to skip a day as Scott suggested as the last time I went 20 hours without a dose I ended up crying hysterically. I do have some benzos on hand if the transition is less than smooth. I don't have much hypotension anymore on 60mg, so I won't need the Ritalin (I'm immune to the mood effects of RItalin anymore anyway). Parnate does work for me with partial improvement at 60mg, so I guess I'll just have to be happy with that. It's just too bad I'll never know if the higher doses might have meant more improvement.
That is all-or-nothing thinking. 80mg might still be the ideal dosage for you.
For the sake of understanding - the appearance of the negative effects of increasing the dose of MAOIs is not instantaneous. They might not be seen until a few days afterwards. It is the nature of the drug mechanism. In other words, one can be lulled into a false sense of safety simply because they don't feel much different immediately after raising the dose. The effects tend to emerge all at once and hit very hard. Likewise, an antidepressant response may not emerge for a few weeks after a dose increase. It is important to consider this when evaluating the efficacy of these drugs.
As to how to handle the dosage reduction, perhaps taking 20mg at 12:00pm and 20mg at 6:00pm will work to even things out. You could then return to 60mg the next day and decide where to go from there.
- Scott
poster:SLS
thread:932472
URL: http://www.dr-bob.org/babble/20100103/msgs/932534.html