Posted by SLS on November 20, 2009, at 8:30:20
In reply to Re: Abilify for anhedonia, posted by SLS on November 20, 2009, at 4:58:28
On second thought:
> > a DA agonist seems like it would make more sense unless you have psychosis on board
> >
> > especially since aripiprazole is super $$
> The only problem with that is that most people develop a tolerance (poop-out) shortly after beginning DA agonist treatment.This seems to be true.
> I don't know, but perhaps there is a downregulation of presynaptic receptors.
This happens, but it is probably not the mechanism behind the "poop-out" effect. I guess downregulation at the postsynaptic makes more sense.
> Using low-dose amisulpride would probably solve that problem, though. Low-dose Abilify might work as well. That would be an interesting combination. I have never seen it done.
I'm thinking that this might still be a good strategy to employ when using a DA agonist. It would prevent the reduction in DA turnover that occurs with these drugs.
- Scott
poster:SLS
thread:926202
URL: http://www.dr-bob.org/babble/20091117/msgs/926318.html