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Re: Litium is neuroprotective? You sure? Breggin?

Posted by SLS on November 11, 2009, at 7:30:25

In reply to Re: Litium is neuroprotective? You sure?, posted by linkadge on November 11, 2009, at 6:59:54

> The other thing is that GKS-3b inhibition produces differential effects on neuroplacticity depending on the phase of development.

What are some of the differences?

For those whom are unfamiliar with GSK-3b inhibition, this is one of the many biological effects of lithium. High levels of GSK-3b are associated with neuronal cell death (apoptosis). This might not always a bad thing, though. In a juvenile developing brain, a process known as pruning must take place to allow the brain to better focus its activity. Pruning allows for the degeneration of unneeded brain tissue. I'm sure Linkadge can describe any association there might be between GSK-3b and pruning.

To remain on topic: Does anyone know what Peter Breggin's views are on the use of lithium?


- Scott

 

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