Posted by g_g_g_unit on November 4, 2009, at 16:17:18
In reply to Re: d-amphetamine + caffeine use in OCD - study » bulldog2, posted by Phidippus on November 4, 2009, at 14:35:45
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> > Are any tricyclic ads capable of nmda antagonism?
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> All ADs modulate glutamate.
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> > How much amantadine is needed for nmda antagonism?
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> amantadine 100-400 mg/day
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> > I wonder if amantadine is easier to tolerate than memantine which really wired me up?
>
> Memantine is a D2 agonist which probably accounts for the wiriness. BUT, Amantadine also does this. Memantine just has a more complicated mechanism of action.
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> P
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>Memantine made me wired too at first. i liked it - i was super social, recovered my cognitive abilities, and could multi-task like nobody's business. but it also drove my compulsions out of control (as opposed to the obsessions). i guess at higher doses the NMDA effect kinda overtakes the D2 agonism, because at 20mg i became a zombie? seems like a really interesting med. just hard to dose.
poster:g_g_g_unit
thread:924126
URL: http://www.dr-bob.org/babble/20091029/msgs/924460.html