Posted by metafunj on October 27, 2009, at 20:09:07
In reply to Re: Do DA agonist and APs increase cognition?, posted by g_g_g_unit on October 27, 2009, at 19:49:17
I appreciate the posts. It seems like any drug that can increase DA transmission may be able to improve at least concentration and maybe even memory.
Regarding Atypical APs. At a low dose they antagonize the D2 autoreceptor. This is the receptor that when activate inhibits the release of dopamine. So when its activated by DA it acts as a DA brake. When you antagonize it you disinhibit the release of DA. This is what low dose APs do. When you take an atypical at a higher dose it starts to block the post synaptic receptor which decreases dopamine transmission. This is presumabley when the antipsychotic part of the medication takes a effect.
Also atypical APs also antagonize certain serotonin receptors that cause the release of more dopamine.
Has Zyprexa or any one else noticed weight gain at these lower doses of APs?
poster:metafunj
thread:922915
URL: http://www.dr-bob.org/babble/20091021/msgs/922987.html