Posted by Rosy Crucifiction on October 26, 2009, at 10:09:26
In reply to Re: zyprexa weight gain, treatment options, posted by Rosy Crucifiction on October 25, 2009, at 12:20:14
Here is a study showing a difference between olanzapine and ziprasidone in glucose tolerance. I do think metformin is a worthwhile addition to atypical antipsychotic therapy.
Original ArticleEffects of Olanzapine and Ziprasidone on Glucose Tolerance in Healthy Volunteers
Julia Sacher1, Nilufar Mossaheb1, Christoph Spindelegger1, Nikolas Klein1, Thomas Geiss-Granadia1, Robert Sauermann2, Edith Lackner2, Christian Joukhadar2, Markus Müller2 and Siegfried Kasper1
Atypical antipsychotics have been linked to a higher risk for glucose intolerance, and consequentially the development of type 2 diabetes mellitus (DM2). We have therefore set out to investigate the acute effects of oral administration of olanzapine and ziprasidone on whole body insulin sensitivity in healthy subjects. Using the standardized hyperinsulinemic euglycemic clamp technique we compared whole body insulin sensitivity of 29 healthy male volunteers after oral intake of either olanzapine 10 mg/day (n=14) or ziprasidone 80 mg/day (n=15) for 10 days. A significant decrease (p<0.001) in whole body insulin sensitivity from 5.7 ml/h/kg (=mean, SM=0.4 ml/h/kg) at baseline to 4.7 ml/h/kg (=mean, SM=0.3 ml/h/kg) after oral intake of olanzapine (10 mg/day) for 10 days was observed. The ziprasidone (80 mg/day) group did not show any significant difference (5.2plusminus0.3 ml/h/kg baseline vs 5.1plusminus0.3 ml/h/kg) after 10 days of oral intake. Our main finding demonstrates that oral administration of olanzapine but not ziprasidone leads to a decrease in whole body insulin sensitivity in response to a hyperinsulinemic euglycemic challenge. Our finding is suggestive that not all atypical antipsychotics cause acute direct effects on glucose disposal and that accurate determination of side effect profile should be performed when choosing an atypical antipsychotic.
poster:Rosy Crucifiction
thread:922057
URL: http://www.dr-bob.org/babble/20091021/msgs/922588.html