Posted by bleauberry on October 6, 2009, at 20:12:13
In reply to LDN Low Dose Naltrexone Questions, posted by Bob on October 5, 2009, at 22:45:53
I have some LDN experience, both from personal use as well as hanging out with other LDN users online.
It is important to respect that LDN accrues longterm benefits slowly. Any initial boost is probably due to some unknown opioid/dopamine/serotonin connection. I felt that too.
The stuff is really powerful. I found 1.5mg was my max dose. Any higher reversed the benefits. I think it is wrong to rush to the doses suggested by others. It is more appropriate to find your own best dose in slow experimentation. LDN is longterm, mistake to rush it.
LDN's primary proposed mechanism is immune modulation/acceleration. This helps fight a wide variety of mysterious complexes such as irritable bowel syndrome, fibro, chronic fatigue, Lyme, other unsuspected infectious bacteria, protozoa, fungi, or virus, MS, and more. Experience shows clearly with a large body of evidence, while analytical research does not (since it hasn't been done) that a significant percentage of all these disorders is caused by an immune dysfunction with a current or past infectious agent as the culprit.
As the immune system is boosted, pathological organisms will be suppressed and killed. That causes die-off. Common symtpoms of die-off include worsened depression, irritibility, oversensitive emotions, anxiety, lack of pleasure, tired, fatigue, insomnia, or oversleep, and worsened pains. All are from the toxic inflammation response.
As stressers are reduced, benefits become apparent steadily. This is usually in the 3 to 6 week range, with perhaps sporadic random moments of feeling good along the journey to feeling more sustained good.
This is a casual non-scientific observation, but it appears to me that approximately 20% of LDN users find it to be a miracle, the next 60% find it to be of significant benefit worth keeping, and the final 20% no benefit. Reports of worsening in any way, depression whatever, are very rare, maybe 5% or less?
So there ya go! Hope it helps.
Hope this helps!
poster:bleauberry
thread:919880
URL: http://www.dr-bob.org/babble/20091001/msgs/920007.html