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Re: sleep on Agomelatine

Posted by Netch on August 7, 2009, at 10:08:54

In reply to Re: sleep on Agomelatine, posted by Alexanderfromdenmark on August 6, 2009, at 17:06:44

> > >just started this medication after being on low dose serzone and am actually finding my sleep is a little worse with some restless legs syndrome. plus i feel a little more depressed. i imagine this is somewhat withdrawal from serzone, but i was curious how long it took for people's sleep to improve on this medication? i was expecting more off the bat. i just increased it to 50mg last night and still woke up ealry this am....
> >
> > Well, I would be the same with that pattern of dosing.
> >
> > If you were to take no more than 25 or 12.5, you would find the sleep thing more or less resolved. That leaves the depression. The first night I took it I took 25 and woke up after a few hours and stayed awake all night, not sleeping until lunch time.
>
> Does agomelatine significantly increase dopamine?

Agomelatine (5-HT2C blockade) raises adrenergic and dopaminergic transmission in frontal cortex.

 

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