Posted by Brainbeard on July 24, 2009, at 8:35:29
In reply to Re: Is Anyone Succesfully Taking Tramadol Long-Term?, posted by SheilaC on July 24, 2009, at 7:20:48
> Do you have any research or info that could be provided to a doc for off label OCD and depression.
There is the Goldsmith and Shapiro study: http://ajp.psychiatryonline.org/cgi/content/full/156/4/660a
They have requested a patent for Tramadol treatment of OCD: http://www.pharmcast.com/Patents/Yr2002/May2002/051402/6387956_Obsesseive051402.htm
For some reason, the patent explicitly talks about PRN use - do the authors smell a rat called 'addiction'?
Tramadol is chemically similar to Effexor, so it would be strange if it wouldn't have antidepressant activity. See: http://books.google.nl/books?id=Qh19Z6WLsqUC&pg=PA235&lpg=PA235&dq=tramadol+chemical+venlafaxine&source=bl&ots=DJz92H_pkz&sig=9ae4SxuCtWM36eTs3vHCrFd9v2U&hl=nl&ei=VLZpSu6ALsv4-AbqiNGLCw&sa=X&oi=book_result&ct=result&resnum=7
Here is a research abstract that concludes: 'we suggest that tramadol has many of the pre- and postsynaptic neurochemical features of a conventional antidepressant, as might be predicted from its pharmacology.': http://opioids.com/tramadol/ultramantidep.html
>It would be the answer to my med problems.
THAT'S the question. It may NOT be, mainly because of tolerance. The question is: How long will you get by on just 50mg a day? That 50mg may not be enough soon.Here's an interesting forum thread where people discuss the benefits vs. the drawbacks of tramadol for (treatment resistant) depression: http://www.drugs.com/forum/featured-conditions/tramadol-depression-33499-3.html
As you can see if you read through it, tolerance is definitely an issue for many (not to mention addiction and the horrible withdrawal syndrome).
Still, some people apparently thrive on 'tram' for years - which, in part, answers my question.
poster:Brainbeard
thread:908301
URL: http://www.dr-bob.org/babble/20090721/msgs/908322.html