Posted by HyperFocus on June 22, 2009, at 17:13:29
In reply to Has anyone else noticed that....., posted by Michael Bell on June 21, 2009, at 23:28:22
> Has anyone else noticed that:
>
> a) medications that have norepinephrine reuptake inhibition as one of their mechanisms of action, such as reboxetine, and tramadol, increase emotional instability, increase the feeling that others are judging you/staring at you, etc., and increase sensitivity to perceived rejection?
~On a high-dose of amitryptiline I'm actually less paranoid immediately after.>
> b) Drugs that are effective for the physiological aspects (heart pounding, sweating, abject terror) of social anxiety, such as klonopin and Nardil, don't help with the "social paranoia" aspect of social anxiety, meaning the beliefs and thought processes that people are looking at them, judghing them negatively, etc.
~Yes benzos work on my anxiety but they don't extinguish any of the destructive thought processes. Years of taking benzos haven't helped my SP change permanently at all.
>
> c) SSRIs + Antipsychotics are pretty damned good for the following: anger outbursts, feelings of frustration, and social parania.
~Haven't had this experience yet.
>
> d) klonopin, on its own, causes depression and anger issues to worsen.
>
~Klonopin makes me anhedonic and very unmotivated - well, more than usual.
> e) drugs that increase dopamine production and availability as the main effect increase anger, frustration and rumination?
~Took amineptine and tianeptine and sulpiride low dose but never noticed this
>
> This has been my general experience with meds. Insofar as social anxiety is concerned, a combination of risperdal plus lexapro has proven much more effective at addressing issues such as anger, suspicion of others' intent, and social paranoia than any other medication, even more than the so called "gold standards" of SP treatment, like Nardil and Klonopin. I've really begun trusting people more and actually looking forward to social gatherings, so I guess the social reward mechanism has very weakly started to kick in. My guess is it will get stronger as time goes by. Also, meds that cause oxytocin release, such as Vilazodone might do, will also probably have profound effects on prosocial behavior.~Also therapy is very important
poster:HyperFocus
thread:902542
URL: http://www.dr-bob.org/babble/20090620/msgs/902640.html