Posted by myco on March 9, 2009, at 23:42:29
In reply to Re: 5-HTP confirmed to lower Tyrosine stimulation » myco, posted by myco on March 9, 2009, at 22:48:22
I hope I dont get in trouble for the 4th post here but....
The idea that inhibiting AADC in the gut to boost effects in the cns is actually the basis for therapy strategies to increase bioavailability of medications. My next nardil experiment will be conducted with green tee extract in slowly increasing doses taken with nardil (same time) on an empty stomach with the cofacter for AADC's (vit B6).
See (for a good new study on this d/r):
Nagai et al. 2009. Inhibitory Effects of Herbal Extracts on the Activity of Human
Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3). Biol Pharm Bull. Jan;32(1):105-9.link:
(http://www.jstage.jst.go.jp/article/bpb/32/1/105/_pdf)
myco------------------------------
> In fact by inhibiting AADC's in the gut you actually increase sythesis of dopamine and seratonin in the cns. There is no detrimental effect I can see based on the results i've looked at.
>
> --------------
>
>
> > AADC's (I know of 3 thus far) act both in the periphery and in the cns.
> >
> > See:
> >
> > Turner et al. 2006. Seratonin a la carte: Supplementation with the seratonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics. Mar;109(3):325-38.
> >
> > in press version available for free here:
> > (http://www.uoregon.edu/~ablackwe/Documents/5-HTP.Pharm.Therap.pdf)
> >
> >
> > ----------------
> >
> > > I've read the opposite in a few studies...seems EGCG doesn't pass the blood brain barrier at all...merely inhibits AADC in the gut resulting in lower periferal seratonin and dopamine.
> > >
> > > ------------
> > >
> > > > i don't know why it was written that would help...if you stop 5ht synthesis in the gut, you also stop it in the brain. EGCG passes the bbb...carbidopa doesn't thats why it is used
> > > >
> > > > -d/r
> > >
> > >
> >
> >
>
>
poster:myco
thread:884577
URL: http://www.dr-bob.org/babble/20090304/msgs/884687.html