Posted by psychobot5000 on December 23, 2008, at 12:23:31
In reply to Re: Agomelatin: could 5HT(2c) action be bad for sl » SLS, posted by Marty on December 23, 2008, at 9:51:29
>
> > Interesting.
> >0057a.html" target="_blank">http://www.nature.com/npp/journal/v28/n2/full/130>0057a.html
>
> Yes, great paper indeed. Makes me think the team who develop Trazodone were on a good track: 5-HT2a antagonist, 5-HT2c agonist (via m-CPP) AND some SRI. If it wasn't of the side effects, in particular the hangover, and if the SRI was stronger it could be an awesome antidepressant if you embrace the thesis discussed in your paper.
>This is all sort of above my head, of course, but isn't nefazodone pretty much what you're describing: trazodone, only with less sedation/hangover, and a (modestly) stronger SRI effect?
poster:psychobot5000
thread:869924
URL: http://www.dr-bob.org/babble/20081223/msgs/870493.html