Posted by bleauberry on December 7, 2008, at 10:24:56
In reply to Re: Strange shift in 5HT tolerances, posted by zzz7 on December 6, 2008, at 18:54:03
I live in the US. You are correct, Milnacipran is not sold in the US. But it is easily available from overseas mailorder. Anyone can order it and receive it within about 2 to 3 weeks.
While Strattera is real strong on NE, it cannot be used a comparison to Milnacipran. Milnacipran is also strong on NE, but in a very different way that I cannot put into words. The meds are only similar when talking about them in general terms on paper. That has zero accuracy in how they are actually dramatically different in how they feel. Strattera to me felt like absolute poison. Milnacipran actually felt kind of good. If someone reacted badly to Strattera and said too much NE, too much DA, whatever, and then said well Milnacipran is like that too so it won't work, they would likely be way wrong.
> Thanks for the reply. I wish I were alone in this. It's no fun.
>
> I've tried Strattera and crashed with it. I suspect it's because NE will affect DA and 5HT levels.
>
> I take tiny bits of Lexapro and put them in capsules I buy from the health foods store. The same goes for the small amounts of amatadine I take.
>
> No Milnacipran here in the US. So that won't work for me.
>
> > Me too. I wish I had some explanation or suggestion for you.
> >
> > I never went to real high doses like you did, but I was on regular doses for a decade. Then after strange developments, paradoxical reactions, poopout, and failed ECT, I am super sensitive as you are. Even a mere 2mg lexapro had me on my knees in uncontrollable tears within 3 days. Anything DA helps a slight bit, but then again, just tiny amounts. Any more and things get worse.
> > Very strange phenomenon.
> >
> > I suspect somewhere along the line receptors just got reconditioned in sensitivity from their artificial environment, or genes got reprogrammed, or something weird.
> >
> > Interesting about sand sized grains of lexapro. I could try that. :-)
> >
> > The only med I have been able to tolerate is low dose Milnacipran. Starting dose is 25mg, therapeutic dose is 50mg to 100mg, max is 200mg, but I felt it extremely strong at just 12.5mg.
> >
> > While 5HT and DA seem messed up somehow, NE seems in better shape. Maybe all those meds didn't mess with NE too much?
> >
> > Anyway, you aren't alone in this weird thing.
>
>
poster:bleauberry
thread:867043
URL: http://www.dr-bob.org/babble/20081204/msgs/867222.html