Posted by bleauberry on September 26, 2008, at 10:28:44
In reply to Nardil-substitute, posted by Medline on September 26, 2008, at 5:12:21
> Nardil (phenelzine) is considered the single most effective, non-addicting drug for Social Anxiety. It works by elevating levels of Serotonin, Dopamine, Norepinephrine and GABA. I think that combining a Selective Serotonin Reuptake Inhibitor (escitalopram) with a Norepinephrine-Dopamine reuptake inhibitor (Bupropion) and a GABA reuptake inhibitor (tiagabine) might be a modern and safe Nardil-substitute. What do you think?
Nope. Totally different mechanisms. Unequal in terms of how much neuros are increased. Very different points of interuption in the neuro biochemistry. Many effects of these meds are unknown or unstudied. Wellbutrin for example is tied into other things such as nitric oxide and nicotinic receptors which may have more to do with its mechanism than norepinephrine or dopamine, since its reuptake inhibition strength of those neuros is actually very weak. The whole neurotransmitter thing is theory, not proven fact, and may be just a tip of the iceberg of what these meds really do to gene instruction, hormone regulation, immune interaction, and such.
Would someone respond real well to the meds you mentioned? Sure. Would they not respond at all? Sure. Would they get a lot worse? Sure. All of the above could happen. Is it a reasonable alternative to Nardil. Imo, No.
poster:bleauberry
thread:854157
URL: http://www.dr-bob.org/babble/20080926/msgs/854183.html