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Re: Parnate + Orthostatic Hypotension » uncouth

Posted by azalea on September 14, 2008, at 1:18:43

In reply to Parnate + Orthostatic Hypotension, posted by uncouth on September 7, 2008, at 10:17:41

How long have you been on Parnate 30mg? Is the orthostatic hypotension improving? Perhaps it is a side effect of the rapid immediate transition from Nardil to Parnate.

Below is copied and pasted information regarding how to manage hypotension as a side effect of other MAOIs. Not sure if this generalizes to Parnate as well.

From "Current Psychiatry" Vol. 1, No. 6 / June 2002
MAO inhibitors: An option worth trying in treatment-resistant cases
Orthostatic hypotension is the most common early side effect
of phenelzine and isocarboxazid. Clinically significant
hypotension is best managed via dosage adjustment. If that
fails, add Na Cl, 1 to 2 grams bid with increased fluids. If that
doesnt work, administer fludrocortisone, 0.1 to 0.4 mg/d. If
that fails, administer d-amphetamine, starting
with 2.5 to 5 mg/d, and observe carefully for
hypertension.


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