Posted by Larry Hoover on August 31, 2008, at 17:51:15
In reply to Re: Questions about Ixel » bulldog2, posted by Racer on August 31, 2008, at 15:43:53
> I'm curious about where these numbers came from, only because I found both the 3:1 and the 9:1 ratios listed for milnaciprine. (And I didn't do the calculations on the raw data I found, which would probably answer my question regarding which is the more accurate number...)
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> Thanks!According to the PDSP database, the milnacipran Ki's for the serotonin and norepinephrine transporters are 151 nm and 68 nm respectively. That would give a norepinephrine to serotonin affinity ratio of 2.22 in favour of NE.
For duloxetine, the serotonin and norepinephrine Ki's are 3.7 and 20 nm, respectively. That would give a ratio of 5.4 in favour of serotonin.
Those are very different, as one modestly favours NE inhibition, and the other somewhat more strongly favours 5-HT inhibition.
Both sets of values arise from one reference (http://www.ncbi.nlm.nih.gov/pubmed/14744476), suggesting that similar laboratory conditions and methodology were used.
Lar
poster:Larry Hoover
thread:849437
URL: http://www.dr-bob.org/babble/20080822/msgs/849524.html