Posted by jrbecker76 on July 29, 2008, at 23:25:35
In reply to Re: Like Trazodone for sleep but w/o heart problems » jrbecker76, posted by johnj on July 27, 2008, at 19:52:31
> Thank you for sharing this info. I know you mentioned before about low doses as you are med sensitive. I am the same. I did try trazodone at 25 mg and slept well but was very hung over the next day. I get the same from remeron except the low doses also make me feel very depressed and I didn't get that from trazodone.
>
> I really just need something to take the edge off and help me sleep somewhat well as this really makes me feel so much better. I was thinking of a small dose nortryptline and maybe serzone.
>
> johnjHi John,
I'd recommend a go of nefazadone first. I'd try out a low-dose of 12.5-50mg. Give it about 1 week to settle into a dose. Despite the fact that nefazadone's half-life is just slightly longer than trazadone's, there is an active metabolite that mimics the parent compound's hypnotic/anxiolytic quality. So, don't up the dose too early. On the other end, for some individuals - despite being sedating for the first half of the night - it can actually cause early awakening. This is most likely due to the m-CPP metabolite. Typically, the activation from m-CPP fades after a week or so of titration for most individuals, but may continue to be a nuisance for some.
My ideal dose was 25mg for quite a few years, but I recently traded that in for the lower dose of 12.5mg in combo with 8 mg of Rozerem. I still sleep soundly, but perhaps not as soundly as I did at the higher dosage level of nefazadone. Given that I'm quite med-sensitive though, I have found that the lower dose gives me less side effects (but now also with less efficacy on antidepressant/anxiolytic effects though).
JB
poster:jrbecker76
thread:842117
URL: http://www.dr-bob.org/babble/20080727/msgs/842983.html