Posted by kieran2585 on May 30, 2008, at 14:06:02
In reply to Mirapex vs. Seroquel for SSRI-induced anhedonia, posted by satsumas on May 30, 2008, at 13:42:55
> Hi friends,
>
> I'm currently taking 300 effexor and am having a terrible time with the apathy, anhedonia, amotivation. Understand that mirapex, and other pro-dop. drugs can help, and i'm currently a few days into a Mirapex trial.
>
> But it seems that there is also research that supports the idea of using low dose antipsychotics like Seroquel or Zyprexa to augment SSRI. Does anyone have experience with adding one of these drugs to their S/NRI, specifically, it's effects on apathy, amotivation, anhedonia, and the perception of having more/less "free will"?
>
> And don't these drugs antagonize dopamine receptors as opposed to mirapex and other stimulants which are pro-DA? So what's the right strategy?i think that stimulation of the 5ht2a/c receptors is what causes ssri induced apathy, zyprexa blocks these receptors increasing cortical dopamine which should help with the apathy you are experiencing, the d2 antagonism is only active for a few hourse after taking a dose, usually while you are asleep, so i wouldnt worry about that too much
poster:kieran2585
thread:832091
URL: http://www.dr-bob.org/babble/20080528/msgs/832093.html