Posted by SLS on May 11, 2008, at 14:34:16
In reply to Re: Does Imipramine Raise Dopamine?, posted by bulldog2 on May 11, 2008, at 12:41:44
> > > I saw an article on the internet that said imipramine prevents reuptake of dopamine in addition to ne and se. The article also said that this med affects the opoid system. Have never read this anywhere else. Any way of verifying these claims?
> > Around 1980, K. Fuxe et al. recorded their observation that imipramine inhibited the reuptake of dopamine in a biphasic manner. More dopamine collected at lower concentrations of imipramine.> What do you mean by biphasic manner? By lower concentrations do you mean at lower doses? Do all tricyclics do this or only imipramine?
Biphasic is sort of like a bell curve. As the concentrations of a TCA rise from zero, the slope of dopamine concentration ascends upwards until a certain threshold is reached, after which the dopamine concentrations descend despite continued escalation of TCA. Two problems come to mind.
First of all, the experiments were carried out in the absence of more modern and reliable measuring implements. The second thing is that no
attempt was made to equate the TCA concentration with a dosage for human use. Perhaps I just didn't see it. Unfortunately, I don't think I can find this study on Medline, although it was indexed in Excerpta Medica in the early 1980s. I think I have the numbers in an old notebook.Other TCAs tested by this investigative team produced similar results.
- Scott
poster:SLS
thread:828449
URL: http://www.dr-bob.org/babble/20080510/msgs/828506.html