Posted by bleauberry on May 4, 2008, at 18:07:47
Came across this at pubmed. It was interesting to see that adding a large dose of SAMe to ssri did not result in serotonin syndrome, and did result in 43% remission of people who had not adequately responded to ssri alone. Despite the usual disclaimer at the bottom indicating a placebo controlled trial is warranted, this small trial did pretty good. I mean, to get a 50% response and 43% remission from any group with one augmentation effort is unusually good.
Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA. [email protected]
BACKGROUND: The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine. METHOD: Thirty antidepressant-treated adult outpatients with persisting major depressive disorder received 800 to 1600 mg of S-adenosyl-L-methionine tosylate over a 6-week trial. RESULTS: Intent-to-treat analyses based on the Hamilton Depression Rating Scale revealed a response rate of 50% and a remission rate of 43% following augmentation with S-adenosyl-L-methionine. Gastrointestinal symptoms and headaches were the most common side effects. CONCLUSION: Augmentation of selective serotonin reuptake inhibitors or venlafaxine with S-adenosyl-L-methionine warrants a placebo-controlled trial in resistant depression.
PMID: 15538131 [PubMed - indexed for MEDLINE]
poster:bleauberry
thread:827188
URL: http://www.dr-bob.org/babble/20080430/msgs/827188.html