Posted by undopaminergic on April 25, 2008, at 0:51:01
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s » Alucard, posted by Sigismund on April 24, 2008, at 2:45:04
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> I don't think 1mg selegeline = 1mg deprenyl citrate sublingual. The sublingual citrate seems stronger to me.
>Any selegiline absorbed directly into the bloodstream (through the sublingual mucous membranes) bypasses first-pass (hepatic) metabolism, which would otherwise convert a large portion of the dose into desmethylselegiline, L-amphetamine and L-methamphetamine, all of which are subject to further metabolism. The amphetamines have no irreversible MAO-inhibitory activity, although they are pharmacologically active in other ways. While desmethylselegiline is an irreversible MAO-B inhibitor, it's considerably less potent as such than selegiline (interestingly, desmethylselegiline seems to have greater neuroprotective potency). In other words, sublingual selegiline produces higher levels of MAO inhibition than oral (swallowed) selegiline.
poster:undopaminergic
thread:825078
URL: http://www.dr-bob.org/babble/20080420/msgs/825321.html