Posted by cumulative on December 3, 2007, at 0:48:01
In reply to Re: D1 stimulation question, for the psychopharm b » DStupid, posted by kingcolon on December 2, 2007, at 23:48:07
Short reply at the moment, I'm on a business trip but I should be getting back tomorrow (and trying out the new pills) so I'll get around to putting in my bit at some of these loose ends.
To my knowledge, the study you cite is the only study that indicated an increased risk for valvulopathy from nonergot drugs, compared to numerous studies that show no correlation. Compare to ergot agonists, which are shown in several studies to increase risk (although certain studies also managed to show no correlation in select groups). This research seems to be a direct response to the research you cite:
http://archneur.ama-assn.org/cgi/content/abstract/64/3/377?ck=nck
Given the major potential usefulness of these drugs, I don't think it's a good idea to promote fear at this point, with so much research indicating that this is not a problem with nonergots. Regular heart exams are a good idea for anyone.
http://www.drug-injury.com/druginjurycom/2007/03/parkinsons_drug.html
"Our practice of recommending non-ergot dopamine agonists as first-line therapy for patients needing a dopamine agonist appears to be relatively safe from the standpoint of cardiac valve function."
poster:cumulative
thread:797696
URL: http://www.dr-bob.org/babble/20071125/msgs/798396.html