Posted by amigan on November 6, 2007, at 11:35:17
In reply to Is trazodone a good hypnotic/sedative?, posted by amigan on November 3, 2007, at 13:05:53
Well, i tried some trazodone yesterday and i'm very disappointed with it.. :-/
At first, i took 50mg and the result was some MILD sedation, dizziness, asthenia and dry mouth. (which is strange because it doesn't have any anti-cholinergic properties)
It was nothing like hydroxyzine, so after 2 hours i took another 50mg. Still, the sedation was not remarkable and the other side effects became more noticeable.. This drug doesn't possess half the potency of hydroxyzine: Just 12.5mg of hydroxyzine (half pill) are enough to knock me out but 100mg of trazodone (a whole pill) are not!
Anyway, after a while, i fell asleep and after seeing some interesting dreams i woke up with a HORRIBLE and looong-lasting headache, (induced by the metabolite mCPP, i suppose) i was nauseous and my stomach was very upset. I was forced to lie down for many hours because of these symptoms.Question: Why everyone experiences extreme sedation, even with lower doses of trazodone, while i don't?
Could i be very sensitive to anti-histamines? (hydroxyzine is a strong anti-histamine, while trazodone is not)
Could it because i'm taking another drug that blocks the action of trazodone? highly unlikely. I only take fluoxetine currently and afaik, it potentiates this drug.Bottom line: Imho, it is not a good drug. It is a rather weak sedative (for me) and it has many nasty side effects.
With hydroxyzine, i experience a strong, clean sedation without any other side effects! What i need is a drug similar to hydroxyzine but with a shorter half-life. Any suggestions? :)
poster:amigan
thread:793133
URL: http://www.dr-bob.org/babble/20071104/msgs/793573.html