Posted by Quintal on August 21, 2007, at 18:23:24
In reply to Re: SSRIs and bone loss » Quintal, posted by Larry Hoover on August 21, 2007, at 17:42:33
>Sorry. I wasn't meaning to sound picky. I just didn't see what you meant.
It seemed to me that the authors expected to find a lower incidence of hip fracture among SSRI users because of this passage: "Selective serotonin-reuptake inhibitors (SSRIs) are reported to be better tolerated than TCAs.". TCAs are usually deemed less tolerable due to their common side effects; sedation, cognitive impairment, and yes certainly orthostatic hypotension and cardiac problems. These side effects are a common cause of falls in the elderly, and falls are the main cause of hip fractures in the elderly. Therefore it would be logical to hypothesize that SSRIs would be associated with lower incidence of hip fractures than TCAs; because they are associated with a lower incidence of these fall-inducing side effects than TCAs. I thought this was the most likely explanation the inclusion of this passage in their report: "Selective serotonin-reuptake inhibitors (SSRIs) are reported to be better tolerated than TCAs.". They found results to the contrary (of what I'm assuming was their hypothesis); that SSRIs were associated with a higher incidence of hip fractures than TCAs, yet still found that treatment with TCAs increased the risk of hip fracture. So that's what I meant.
Q
poster:Quintal
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777646.html