Posted by Jedi on July 28, 2007, at 22:01:14
In reply to Re: To Nardil or not to Nardil? » Jedi, posted by Sentience on July 28, 2007, at 20:18:13
> A few things. Firstly, You mention a rather rapid turn-around of discontinuing the Nardil & then commencing the Parnate, within 1 month. I can understand the reasoning for wanting to intervene before the depression took root. I guess many people could do that & experience no untoward reactions. However, in your case, I'm wondering if the hypertensive crises were due to an insufficient washout of the Phenelzine. MAOIs are known to interact and a minimum 14 washout is recommended. Just a thought, as you say, other than that you responded well to the Parnate.
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I don't believe my hypertensive problems with tranylcypromine were related at all to washout of phenelzine. When the problem happened, I had been completely off phenelzine for almost three months. The spontaneous hypertensive reaction is just a rare side effect that happens sometimes in very few people.
References:
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=8399806&ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSumhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=2486182&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
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> ... I'm wondering if its not so much the Phenelzine per se, or whether it's due to some induced change in metabolism as a result of MAO inhibition.
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I know that Phenelzine causes intense sweet carbohydrate cravings in many users, especially me. It may also have an affect on metabolism. Tranylcypromine, on the other hand, does not seem to cause weight gain in most people. Weight loss is more common. Since both medications inhibit monoamine oxidase, I don't think that MAO inhibition caused my weight gain.
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> Have you ever tried Omega 3 supplementation for the chronic low level dysthymia you mention? My understanding of how the Omega 3 tricglycerides work is that they basically exert their main effect by reducing the viscosity of cell membranes... In this instance the neuron membrane. ...
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Yes, I have been taking fairly high doses of Omega-3 fatty acids for at least 18 months. It has not seemed to help my mood problems but I think that the scientific evidence to their health benefits is becoming substantial. I currently take 1800mg of EPA and 1200mg of DHA on a daily basis.Thanks again for sharing your situation.
Jedi
poster:Jedi
thread:772210
URL: http://www.dr-bob.org/babble/20070719/msgs/772633.html