Posted by Squiggles on July 28, 2007, at 13:14:22
In reply to Re: Should all drugs be generic? » Squiggles, posted by Larry Hoover on July 28, 2007, at 12:51:03
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11999908
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> LarI can find many articles and recent researches on this (see LITHIUM IN NEUROPSYCHIATRY - Bauer, Grof, and Mu[..]ller-Oerlignhausen) that say the contrary.
In the majority of cases, lithium inhibits thyroid hormone secretion rate by an increase in TSH concentration. Sometimes goiter and enlargement of the thyroid results. In some interesting, rare case there is the phenomenon of hyperthyroidism-- but that is a clinical oddity; is this what you are referring to by toxicity?
Also, let me remind you that patients on lithium are regularly checked for TSH function.
And in my case, i have been on lithium since i think about 1986, and have a steady level of creatine clearance, and TSH, with the TSH lowered in the first couple of years and remaining at a level where Synthroid was required, and the dose changed 2 or 3 x since. Therefore, you could say I am stable.
Furthermore, if i did try to get off lithium, given a stable state which others might envy on other drugs, it is not a certain that the thyroid gland could be reversed to its initial natural state.
P.S. Could you please approach a milder tone with me; you seem irritated by my posts or me.
Squiggles
poster:Squiggles
thread:772306
URL: http://www.dr-bob.org/babble/20070719/msgs/772549.html