Posted by linkadge on May 25, 2007, at 16:31:09
In reply to Re: Some questions about Lithium. » linkadge, posted by Squiggles on May 25, 2007, at 14:36:35
Raising serotonin levels to high will affect melatonin excretion via stimulation of 5-ht2a. Drugs that block 5-ht2a such as atypicals, mirtazapine, trazodone etc have some ability to block this effect.
SSRI's can cause insomnia by affecting this serotonin melatonin ballance.
As much as it may seem, I'm not totally pulling this stuff out of my...
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See:
http://www.gianteagle.com/healthnotes/Drug/Fluoxetine.htm
Administration of fluoxetine for six weeks significantly lowered melatonin levels in people with seasonal affective disorder (SAD) and in healthy persons as well.3 Further study is needed to determine if this might interfere with sleeping or whether melatonin supplementation might be appropriate.
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I have seen similar studies for other SSRI's, so I am assuming this could be a class effect. (Except for fluvoxamine which actually increases melatonin by affecting its metabolism).
Any other q's??Linkadge
poster:linkadge
thread:759071
URL: http://www.dr-bob.org/babble/20070524/msgs/759484.html