Posted by Squiggles on April 21, 2007, at 14:54:42
In reply to Re: Drugs metabolized by the liver » Squiggles, posted by Larry Hoover on April 21, 2007, at 14:39:06
>
> Just to be clear, there is a liver interaction. Both drugs are processed by liver enzyme 3A4. There is also a functional interaction, as both drugs have sedating qualities.
>
I know that a chronic exposure to imipramine, like many other psychiatric drugs may have wearing
effect on the brain, e.g. dopamine depletion. So that's one avenue of exploration.It could many things:
- too high an imipramine dose
- too high a K dose
- interaction between the two
- post gastro surgery effect on the metabolism of the drug
- Serzone after the surgery affecting the liver
- and one more thing-- this version of imipramine has been recently introduced. It may just be very weak in comparison to other brands, as they are not introducing generic versions. I have had generic versions which were weak. So this sleepiness may actually be a DEPRESSSION as a result of a weak imipramine.Yes, i know i have a hyperactive imagination; never let a stone unturned, unless the worms have now made their home under there. :-)
Quality of life sucks! It's pathetic. I don't know how doctors have the gall to criticize lithium, and be puritanical about opiates.
Squiggles
poster:Squiggles
thread:744916
URL: http://www.dr-bob.org/babble/20070419/msgs/752043.html