Posted by Larry Hoover on April 5, 2007, at 6:40:27
In reply to New med Serzone any experiences?, posted by Phillipa on April 4, 2007, at 17:08:57
> Well the pdoc is starting me on serzone know it carries a black box warning for liver. Anyone know anything about it or take? I am as usual frightened as I told him about the benzo withdrawal he said no. I'm so anxious it said it would be good for insomnia and anxiety. Along with the valium. Love Phillipa ps saw the therapist first who stirred up med and trust issues with me. Poor timing.
Nefazodone profoundly inhibits the function of two workhorse enzymes, 3A4 and 2D6, which is probably the underlying mechanism by which liver toxicity occurs in vulnerable people. Valium is a substrate for 3A4, so you're going to get an interaction there. You're going to get an increased AUC for this drug, meaning prolonged and enhanced effect. Considering your symptoms, this may be beneficial. Be wary, though, that you may develop symptoms of overdose, including dizziness and loss of coordination. Just take it easy until you get used to it. And whatever you do, no alcohol!
Lar
poster:Larry Hoover
thread:746967
URL: http://www.dr-bob.org/babble/20070402/msgs/747149.html