Posted by rjlockhart on March 9, 2007, at 18:54:20
In reply to Re: Amphetamine is a releaser a reuptake inhibitor, posted by rjlockhart on March 9, 2007, at 18:39:59
another source.
http://corp.aadac.com/other_drugs/the_basics_about_other_drugs/amphetamines_beyond_abcs.asp
"Amphetamine enters nerve terminals and displaces neurotransmitter molecules (noradrenaline, dopamine) from storage areas within the nerve terminal. This results in an increase in the release of transmitter from the terminal during periods of rest. It is not necessary for the nerve itself to be stimulated for this sort of release to take place. Such release increases the activity of the organ system serviced by that nerve even when this activity is not needed.Amphetamine also prevents re-uptake of neurotransmitters (noradrenaline, dopamine) into the nerve terminal after release. Typically, nerves recycle transmitter substances, releasing them in response to a nerve impulse and taking the transmitter back into the terminal during rest periods. Thus, the action of released neurotransmitters is made more powerful by decreased neuronal reuptake, producing exaggerated cellular responses.
Because nerves have efficient re-uptake mechanisms, they normally do not need to synthesize large amounts of transmitter; thus, the ability of these nerves to synthesize new transmitter is limited. If the re-uptake mechanism is inhibited by amphetamine, transmitter that cannot get back into the nerve terminal will ultimately be destroyed. If high doses of amphetamines are taken over an extended period, the nerve terminal can become depleted of transmitter. Recovery after long periods of amphetamine use cannot occur until these nerve terminals synthesize enough transmitter to fulfill their functional duties. "
poster:rjlockhart
thread:739475
URL: http://www.dr-bob.org/babble/20070308/msgs/739624.html