Posted by yxibow on February 26, 2007, at 2:50:35
In reply to Playcidyl, posted by Quintal on February 25, 2007, at 19:08:21
> Ethchlorvynol
>
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> (Redirected from Placidyl)
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>
> Ethchlorvynol
> Systematic (IUPAC) name
> 1-chloro-3-ethyl-pent-1-en-4-yn-3-ol
> Identifiers
> CAS number 113-18-8
> ATC code N05CM08
> PubChem 3281
> DrugBank APRD00958
> Chemical data
> Formula C7H9ClO
> Mol. weight 144.598 g/mol
> Pharmacokinetic data
> Bioavailability ?
> Protein binding 35-50%
> Metabolism ?
> Half life ?
> Excretion ?
> Therapeutic considerations
> Pregnancy cat. ?
>
> Legal status Schedule IV[1]
>
> Routes Oral
> Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.
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> Along with expected sedative effects of relaxation and drowsiness ethchlorvynol can cause skin rashes, faintness, restlessness and euphoria. Early adjustment side effects can include nausea and vomiting, numbness, blurred vision, stomach pains and temporary dizziness. An overdose is marked by confusion, fever, peripheral numbness and weakness, reduced coordination and muscle control, slurred speech, reduced heartbeat.
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> It is addictive and after prolonged use can cause withdrawal symptoms including convulsions, hallucinations and memory loss. Due to these problems it is unusual for ethchlorvynol to be prescribed for periods exceeding seven days.
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> Ethchlorvynol is a member of the class of sedative-hypnotic tertiary carbinols such as methylparafynol. It is not a barbituric acid derivative. The systematic name of ethchlorvynol is usually given as ethyl 2-chlorovinyl ethynyl carbinol or 1-chloro-3-ethyl-1-penten-4-yl-3-ol. Its empirical formula is C7H9ClO. In the United States Abbott Laboratories used to sell it under the tradename Placidyl. During their heyday, they were known on the street as "jelly-bellies". Since Abbott and Banner Pharmacaps, which manufactured the generic version, discontinued production in 1999, ethchlorvynol is no longer available in the United States.
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>
> Placidyl is the drug which William Rehnquist was prescribed for insomnia after back surgery in 1971, according to FBI files obtained after Rehnquist's death. Before he was hospitalized in 1981, court employees noticed that Rehnquist's speech was slurred and that he seemed to be having mental lapses. The hospital doctors took him off the medication, causing withdrawal symptoms which included hallucinations. [2]
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> One of the physicians who treated Rehnquist for Placidyl withdrawal, according to the FBI files, described auditory hallucinations in the form of voices discussing him outside his hospital room. At one point the Justice tried to flee the hospital in his pajamas specifically because of the mistaken belief that the CIA was plotting against him.[3]
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> http://en.wikipedia.org/wiki/Placidyl
>
> Q
I believe the manufacturing of Placidyl and possibly Cloral Hydrate involved CFCs, and its unpopularity and possibly that reason may have lead to its discontinuation, but I'm not sure.
poster:yxibow
thread:735434
URL: http://www.dr-bob.org/babble/20070224/msgs/736339.html