Posted by psychobot5000 on February 25, 2007, at 11:18:42
In reply to Re: MAO-A elevated in major depression, posted by linkadge on February 23, 2007, at 11:53:08
> Perhaps an arguement for lower dose MAOI's. Perhapse we don't need 80% inhibition of MAO-A in order to achieve theraputic response.
>
Except (I would say) that experienced practicioners with MAOis inevitably find their patients respond better when they push and push the dosages--often well-above the DSM-recommended ranges.That said...tranylcypromine is most useful to me in absurdly low dosages, it seems.
Also, for all the focus on MAO-a, this type of data does not seem to accound for selegiline/Emsam's apparently greater efficacy than Moclobemide--which meta-analyses show is sligtly less effective than SSRIs. Practitioners in European countries have apparently been disappointed with it.
poster:psychobot5000
thread:734868
URL: http://www.dr-bob.org/babble/20070224/msgs/736009.html