Posted by SLS on January 26, 2007, at 6:00:40
In reply to SLS - riluzole!!!, posted by rovers95 on January 26, 2007, at 4:51:51
> Hi scott, hope you are doing ok - having responded again to Ket i am seriously looking into trying riluzole (it seems a safer long-term option to me)......seen as you seem, like me, to have gathered knowledge with regards to glutamate based drugs i was just wondering if you knew whether riluzole, like ket and magnesium, has pro dopaminergenic properties due to its NMDA antagonism???
I don't know for sure. I would have to dig around to find out. I think glutamate release inhibition certainly can, though. Doing so produces a disinhibition of dopamine release in the nucleus accumbens if I remember correctly. Both Lamictal and Riluzole share this property. If you can afford it, I wouldn't discourage you from trying Riluzole, despite my failure to respond to it. Actually, it exacerbated my depression after only 3 days and at a dosage of 100mg. Many drugs exacerbate my depression, and I have been treatment-resistant, so my case should not be used as a model of any type of response pattern to a given drug.
I wish you luck with riluzole. I don't see how it makes sense to exclude it from consideration.
- Scott
poster:SLS
thread:726603
URL: http://www.dr-bob.org/babble/20070125/msgs/726608.html