Posted by Paulbwell on December 15, 2006, at 0:56:22
In reply to Re: Why Are Dopamine Agonists Not More Popular?, posted by psychobot5000 on December 14, 2006, at 16:50:04
> I've wondered about those interactions too. ...Don't know enough about it to say what exactly they mean...but in my experience, antipsychotics didn't really seem to block the effect of low-dose stimulants. Of course it was different, taking them together. But Risperdal and most of its brothers (except Amisulpride and abilify?) I believe are all D2 antagonists, which seems as though it ought to put them in direct opposition to agonists like Pramipexole and bromocriptine. Perhaps that specific is all they mean.
-RISPERDAL:risperidone Risperdal, Risperidal, Belivon, Risperin, Rispolept, Rispolin antipsychotic, depression AP: 4-16mg
AD: 0.5mg-2mg RM: 3 hrs
SM: 20 hrs
CYP-3A
P-gp * benzisoxazole:
neuroleptic
DA2 antagonist ++
5-HT2a antagonist +++
NE-alpha antagonist ++
H1 antagonist +-DEXEDRINE:
dextroamphetamine
(d-amphetamine) Dexedrine, DextroStat ADD, ADHD, narcolepsy, obesity 5-30mg
(40mg max) 10-25 hrs
CYP-2D6 * psychostimulant:
NE release +++
DA release ++
DA reuptake inhibition +
NE reuptake inhibition +
-RITALIN:methylphenidate Ritalin, Concerta, Metadate, Methylin, Methylphen ADD, ADHD, depression, CFS 20-30mg
(60mg max) 2.9 hrs * psychostimulant:
DA reuptake inhibition
NE reuptake inhibition
NE release-ADDERALL:
amphetamine
(mixed salts) Adderall, Biphetamine ADD, ADHD, narcolepsy, depression, AD sexual side-effects 5-40mg
(60mg max) 10-25 hrs
CYP-2D6 * psychostimulant:
NE release +++
DA release ++
DA reuptake inhibition +
NE reuptake inhibition +-DESOXYN:
methamphetamine Desoxyn, Methampex, Methedrine, Pervitin, Temmler ADD, ADHD, obesity 10-25mg 10-25 hrs
CYP-2D6 * psychostimulant:
5-HT release +++
NE release +++
DA release ++
DA reuptake inhibition
NE reuptake inhibitionInteresting that Risperdal blocks DA2 receptors, along with NE-alpha receptors, which in low AD doses (.25-1mg) shouldn't be TOO noticable, but raise the dose to AP levels, and it'll make thoes Stims struggle.
I wonder what AP and stim, you used and the doses?
Cheers
poster:Paulbwell
thread:712252
URL: http://www.dr-bob.org/babble/20061212/msgs/713838.html