Posted by dbc on December 9, 2006, at 9:01:39
In reply to Re: EMSAM for ADHD » dbc, posted by saturn on December 9, 2006, at 8:50:38
Even if the amphetamine were active it wouldnt be at a level that would matter anyway. As far as i know no MAOIs produce enough Mamp to impact anything.
J Child Adolesc Psychopharmacol. 2004 Fall;14(3):418-25.
Selegiline in comparison with methylphenidate in attention deficit hyperactivity disorder children and adolescents in a double-blind, randomized clinical trial.
Mohammadi MR, Ghanizadeh A, Alaghband-Rad J, Tehranidoost M, Mesgarpour B, Soori H.
Department of Psychiatry, Tehran University of Medical Sciences, Psychiatry and Clinical Psychology Research Center, Roozbeh Hospital, Tehran, Iran., National Research Center for Medical Sciences (NRCMSI), Tehran, Iran.Objectives: The aim of this study was to examine the selegiline treatment compared to methylphenidate (MPH) in children and adolescents with attention deficit hyperactivity disorder (ADHD). Method: Forty subjects, aged 6-15 years, boys and girls, who were diagnosed as having ADHD, using the criteria of the Diagnostic and Statistical Manual of Mental Disorders- Fourth Edition (DSM-IV), were randomly assigned to receive either selegiline or MPH for 60 days. Treatment outcomes were assessed using the Attention Deficit Hyperactivity Scale (ADHS) administered at baseline and on days 14, 28, 42, and 60 following the commencement of treatment. Side effects were also rated. Results: There were no significant differences between sex, age, weight, and ethnicity of participants in the 2 groups. Both groups showed a significant improvement over the 60 days of treatment resulting from the teachers' and parents' ADHS scores across the treatment. Conclusion: Following the trial, MPH did not effect greater mean improvement as a result of the parents' or teachers' ADHS scores than selegiline. Thus, selegiline appears to be effective and well tolerated for ADHD in children and adolescents.
http://www.lifestages.com/health/attentio.html
The study does deal with selegline but of course logically EMSAM would be prefered over it in most situations aside from its cost.
poster:dbc
thread:711712
URL: http://www.dr-bob.org/babble/20061206/msgs/711815.html