Posted by hgi698 on December 1, 2006, at 16:47:11
In reply to Questions regarding BuSpar efficacy DA binding and, posted by saturn on November 27, 2006, at 15:06:53
"Buspirone is a partial agonist at serotonin 5-HT1A receptors (17). It also acts as an antagonist at dopamine D2 receptors, but its affinity for these receptors is 16-fold weaker than its affinity for 5-HT1A receptors (18)."
Thus, the dose of buspirone to block the D2 receptor would have to be 16 fold higher than the dose needed for agonism of the 5-ht1a receptor. Since it is relatively selective I wouldn't worry about it. There's indication that buspirone can be pro-sexual too which would indicate and increase in dopaminergic neurotransmission.
poster:hgi698
thread:707906
URL: http://www.dr-bob.org/babble/20061129/msgs/709460.html