Posted by SLS on September 18, 2006, at 9:36:41
In reply to Re: Tonight I don't feel that antidepressants work » linkadge, posted by llrrrpp on September 18, 2006, at 8:20:47
> Oh, I wanted to add one little thing about AD studies.
>
> Where do they find research subjects who have a diagnosis of Major Depression, with no other concommitant substance abuse issues, psychological, medical or psychiatric disorders?Yes. I believe the inclusion criteria have become wider and wider, and the exclusion criteria perhaps less stringent. The numbers for the same drugs that were tested 20 years ago have changed significantly and demonstrate reduced efficacy with placebo response rates going higher and higher. How can this be? Clinical trials must be examined and redesigned with particular attention payed to the definition of Major Depressive Disorder or Bipolar Disorder, the revison of subject selection criteria, and the scrutinization and standardized of rating scales.
- Scott
poster:SLS
thread:686696
URL: http://www.dr-bob.org/babble/20060909/msgs/687052.html