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Re: Focalin +/- clomipramine to function well? SLS

Posted by Keith Talent on August 1, 2006, at 0:00:52

In reply to Re: Focalin +/- clomipramine to function well? SLS, posted by SLS on July 31, 2006, at 21:00:37

> Have you been diagnosed as having ADD?
No, this was excluded.

> What prevents you from getting work done?
When I'm depressed, I have the atypical pattern of hyper(somnia/phagia). When on an antidepressant, the anhedonia is helped much more than the anergia.

> How well does it work?
It gets me to a point of subjectively feeling good, albeit with some residual lack of get up and go.

> What happens after four weeks?
There's nothing significant about the four week point. The adverse effects start within one day. The problem is, the clomipramine (250 mg/d) makes me feel well enough that I can no longer tolerate the anorgasmia, tachycardia, sweating, dry mouth etc.

> > Dextroamphetamine worked, but only for eight weeks; then it made me exhausted.
> In what ways did it work for you?
It rounded out the recovery, if you will. The sluggishness vanished. Family and friends commented on this.

> Were you taking clomipramine at the same time?
No, I was on sertraline and clonazepam during that time.

> > Is Focalin (dexmethylphenidate) likely to offer any greater sustainability of clinical benefits, due to its merely blocking dopamine reuptake, rather than both causing dopamine release AND blocking reuptake (a la the amphetamines)?
>
> That is a very reasonable line of thinking. It might be worth a try.
>
> My other two thoughts were to explore using Wellbutrin as an antidepressant or Provigil as an adjunct.
>
> Sorry I couldn't be of more help.
On the contrary - thanks for taking the time to give your expert opinion, Scott.

Keith


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poster:Keith Talent thread:672302
URL: http://www.dr-bob.org/babble/20060724/msgs/672465.html